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In spin-off media and the novels in particular, the Gallifreyans were "cursed" with sterility and Rassilon engineered the looms to "grow" children from the template of other individuals - hence genetic "houses" rather than direct lineage. However, this is often overlooked by the show itself as in the parental link between the Doctor and Susan as well as multiple references to the Doctor having, or at least had, children of his own.