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Although it has been hinted that River is aware of all the Doctor's regenerations (or at least the first eleven) there has been no indication on screen that she has actually interacted with any Doctors before Ten, nor that she ever encountered Ten before the events of the Library (certainly from Ten's perspective they'd never met). Although there is some speculation relating to a line in "A Good Man Goes to War" about her meeting more than one Doctor on her birthday, it was later indicated that this occurred during one of the DVD/Blu-ray "Night and the Doctor" mini-episodes involving two versions of Eleven.