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In his timeline, they first met in the Library ("Silence in the Library"/"Forest of the Dead"). In her timeline, they first met when she was the apparent age of about 9 or 10 & was trapped in a spacesuit in Florida ("The Impossible Astronaut"/"Day of the Moon").

The Doctor initially believed that he had met baby Melody Pond (River Song) in "A Good Man Goes to War" but discovered that the baby had been replaced by a ganger to conceal her kidnapping by Kovarian & the Silence.