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We do not know. On screen she was last seen (in her chronology) in "The Five Doctors", but it is not known whether the First Doctor took her back to 22nd century earth or returned to her Gallifrey. In the audio dramas, she continued to live on in the 22nd century and had children ("Relative Dimensions" (audio story), et al). The Ninth Doctor suggested that his entire family was dead in "Father's Day", but given the events of "The Day of the Doctor" we don't know if this is true anymore.