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Melody was kidnapped and brainwashed to kill the Doctor by Madame Kovarian (who worked for The Silence). She was later revealed to be Mels, Amy and Rory's childhood friend.
She regenerated into the woman known as 'River Song'. Paradoxically, this name was given to her by the Doctor because the Doctor knew her as River Song in her future and his past, meaning the name River Song was created for her because the name was created for her. A similar thing happens with the name Melody, as she was named originally after Amy and Rory's childhood friend who just so happened to be Melody Pond, Amy and Rory's daughter. Basically, she was named after herself.