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Two babies played baby Melody in "A Good Man Goes to War": Harrison and Madison Mortimer.

Sydney Wade played young Melody ("Little Girl") in "The Impossible Astronaut"/"Day of the Moon" & made Doctor Who history with the first on-screen regeneration of a female character (Romana's regeneration was off-screen).

Maya Glace-Green played young Melody (Mels) in "Let's Kill Hitler".

Nina Toussaint-White played the adult -- but still fairly young -- Melody (Mels) in "Let's Kill Hitler".