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In "A Good Man Goes to War", River Song says the word "Doctor", in the context of referring to someone who helps, came from the Doctor, the Time Lord, presumably due to his presence throughout history. However it is not known which incarnation of the Doctor was responsible (directly or indirectly) for starting the ball rolling. That said, in "Nothing O'Clock" (short story), the Eleventh Doctor travels to a point prior to the original Big Bang. This is the earliest known presence of the Doctor, which would make this incarnation the "first Doctor in history".